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BRENDA KEGG MetaCyc

purine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP
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-
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-
natural substrates
formate-phosphoribosylaminoimidazolecarboxamide ligase
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: purP
natural substrates
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
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natural substrates
ADP-ribose diphosphatase
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
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-
natural substrates
ADP-sugar diphosphatase
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
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-
natural substrates
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate
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natural substrates
dGTP + H2O = dGMP + diphosphate
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natural substrates
dUTP diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
8-oxo-dGTP diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
2-hydroxy-dATP diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
(d)CTP diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
ATP diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
nucleotide diphosphatase
dGTP + H2O = dGMP + diphosphate
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-
natural substrates
purine nucleosidase
xanthosine + H2O = D-ribose + xanthine
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-
natural substrates
inosine nucleosidase
xanthosine + H2O = D-ribose + xanthine
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-
natural substrates
uridine nucleosidase
xanthosine + H2O = D-ribose + xanthine
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-
natural substrates
ribosylpyrimidine nucleosidase
xanthosine + H2O = D-ribose + xanthine
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-
natural substrates
purine-nucleoside phosphorylase
deoxyguanosine + phosphate = guanine + alpha-D-deoxyribose 1-phosphate
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-
natural substrates
guanosine phosphorylase
deoxyguanosine + phosphate = guanine + alpha-D-deoxyribose 1-phosphate
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-
natural substrates
thymidine phosphorylase
deoxyguanosine + phosphate = guanine + alpha-D-deoxyribose 1-phosphate
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-
natural substrates
adenine deaminase
adenine + H2O = hypoxanthine + NH3
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-
natural substrates
purine-nucleoside phosphorylase
guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate
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: This is a specific case of the non-specific reaction catalyzed by purine-nucleoside phosphorylase |FRAME:PNP-RXN|. Even though a different EC reaction (EC 2.4.2.15) describes this specific reaction, the E. coli enzyme has been associated with this reaction, since EC 2.4.2.15 was defined for a much more specific rabbit bone marrow enzyme [14008731].
natural substrates
guanosine phosphorylase
guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate
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-
: This is a specific case of the non-specific reaction catalyzed by purine-nucleoside phosphorylase |FRAME:PNP-RXN|. Even though a different EC reaction (EC 2.4.2.15) describes this specific reaction, the E. coli enzyme has been associated with this reaction, since EC 2.4.2.15 was defined for a much more specific rabbit bone marrow enzyme [14008731].
natural substrates
S-methyl-5'-thioadenosine phosphorylase
guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate
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-
: This is a specific case of the non-specific reaction catalyzed by purine-nucleoside phosphorylase |FRAME:PNP-RXN|. Even though a different EC reaction (EC 2.4.2.15) describes this specific reaction, the E. coli enzyme has been associated with this reaction, since EC 2.4.2.15 was defined for a much more specific rabbit bone marrow enzyme [14008731].
natural substrates
purine-nucleoside phosphorylase
inosine + phosphate = hypoxanthine + alpha-D-ribose 1-phosphate
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natural substrates
guanosine phosphorylase
inosine + phosphate = hypoxanthine + alpha-D-ribose 1-phosphate
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-
natural substrates
S-methyl-5'-thioadenosine phosphorylase
inosine + phosphate = hypoxanthine + alpha-D-ribose 1-phosphate
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-
natural substrates
uridine phosphorylase
inosine + phosphate = hypoxanthine + alpha-D-ribose 1-phosphate
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-
natural substrates
S-methyl-5'-thioinosine phosphorylase
inosine + phosphate = hypoxanthine + alpha-D-ribose 1-phosphate
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-
natural substrates
phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
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: intermediate (see [CPD:C01151])
natural substrates
phosphopentomutase
alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
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: intermediate (see [CPD:C01151])
natural substrates
deoxyribose-phosphate aldolase
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
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-
natural substrates
phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
Deoxyribose 1-phosphate = Deoxyribose 5-phosphate
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: intermediate (see [CPD:C04175])
natural substrates
phosphopentomutase
Deoxyribose 1-phosphate = Deoxyribose 5-phosphate
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: intermediate (see [CPD:C04175])
natural substrates
phosphomannomutase
Deoxyribose 1-phosphate = Deoxyribose 5-phosphate
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: intermediate (see [CPD:C04175])
natural substrates
purine-nucleoside phosphorylase
adenine + deoxyribose 1-phosphate = deoxyadenosine + phosphate
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natural substrates
S-methyl-5'-thioadenosine phosphorylase
adenine + deoxyribose 1-phosphate = deoxyadenosine + phosphate
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natural substrates
adenosine-phosphate deaminase
2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3
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natural substrates
ATP deaminase
2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3
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natural substrates
adenosine deaminase
2'-deoxyadenosine + H2O = 2'-deoxyinosine + NH3
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natural substrates
deoxyguanosine kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
deoxynucleoside kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
adenosine kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
thymidine kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
deoxycytidine kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
2'-deoxyadenosine kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
broad specificity nucleoside kinase
ATP + 2'-deoxyadenosine = ADP + dAMP
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natural substrates
(deoxy)adenylate kinase
ATP + dAMP = ADP + dADP
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natural substrates
(deoxy)nucleoside-phosphate kinase
ATP + dAMP = ADP + dADP
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natural substrates
adenylate kinase
ATP + dAMP = ADP + dADP
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natural substrates
nucleoside-phosphate kinase
ATP + dAMP = ADP + dADP
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natural substrates
(deoxy)nucleoside-phosphate kinase
ATP + a 2'-deoxyribonucleoside 5'-phosphate = ADP + a 2'-deoxyribonucleoside 5'-diphosphate
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-
natural substrates, nucleotide
glycine reductase
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
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natural substrates, generic
formimidoyltetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
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natural substrates
glycine formimidoyltransferase
5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine
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natural substrates
aminoimidazolase
4-aminoimidazole + H2O = imidazol-4-one + NH3
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natural substrates
xanthine dehydrogenase
6,8-dihydroxypurine + NAD+ + H2O = urate + NADH
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natural substrates
xanthine dehydrogenase
2 hypoxanthine + 2 NAD+ + 2 H2O = xanthine + 6,8-dihydroxypurine + 2 NADH + 2 H+
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natural substrates
xanthine dehydrogenase
purine + NAD+ + H2O = 8-hydroxypurine + NADH + H+
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-
natural substrates
phosphoribosylaminoimidazole carboxylase
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
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natural substrates
5-(carboxyamino)imidazole ribonucleotide mutase
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
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natural substrates
guanosine deaminase
guanosine + H2O = xanthosine + NH3
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natural substrates
xanthine dehydrogenase
hypoxanthine + NAD+ + H2O = xanthine + NADH
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natural substrates
xanthine oxidase
hypoxanthine + NAD+ + H2O = xanthine + NADH
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natural substrates
purine nucleosidase
inosine + H2O = D-ribose + hypoxanthine
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natural substrates
inosine nucleosidase
inosine + H2O = D-ribose + hypoxanthine
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natural substrates
adenosine nucleosidase
inosine + H2O = D-ribose + hypoxanthine
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natural substrates
ribosylpyrimidine nucleosidase
inosine + H2O = D-ribose + hypoxanthine
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natural substrates
alkaline phosphatase
IMP + H2O = inosine + phosphate
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natural substrates
acid phosphatase
IMP + H2O = inosine + phosphate
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natural substrates
5'-nucleotidase
IMP + H2O = inosine + phosphate
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natural substrates
IMP-specific 5'-nucleotidase
IMP + H2O = inosine + phosphate
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natural substrates
purine nucleosidase
guanosine + H2O = D-ribose + guanine
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natural substrates
inosine nucleosidase
guanosine + H2O = D-ribose + guanine
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natural substrates
adenosine nucleosidase
guanosine + H2O = D-ribose + guanine
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natural substrates
ribosylpyrimidine nucleosidase
guanosine + H2O = D-ribose + guanine
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natural substrates
alkaline phosphatase
guanosine monophosphate + H2O = guanosine + phosphate
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natural substrates
inositol-phosphate phosphatase
guanosine monophosphate + H2O = guanosine + phosphate
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natural substrates
5'-deoxynucleotidase
guanosine monophosphate + H2O = guanosine + phosphate
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natural substrates
ribonucleoside-triphosphate reductase (thioredoxin)
ATP + reduced thioredoxin = dATP + oxidized thioredoxin + H2O
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natural substrates
ribonucleoside-diphosphate reductase
ADP + reduced thioredoxin = dADP + oxidized thioredoxin + H2O
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natural substrates, generic
ribonucleoside-triphosphate reductase (thioredoxin)
ADP + reduced thioredoxin = dADP + oxidized thioredoxin + H2O
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natural substrates, generic
adenylosuccinate synthase
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
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-
natural substrates
phosphoribosylglycinamide formyltransferase
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
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natural substrates
phosphoribosylformylglycinamidine synthase
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
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natural substrates
phosphoribosylformylglycinamidine cyclo-ligase
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
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natural substrates
5-(carboxyamino)imidazole ribonucleotide synthase
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+ = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
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natural substrates, nucleotide
5-(carboxyamino)imidazole ribonucleotide mutase
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
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: The EC number 5.4.99.18 has been proposed for this reaction, but has not been approved yet.
natural substrates
phosphoribosylaminoimidazolesuccinocarboxamide synthase
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
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natural substrates
adenylosuccinate lyase
(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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natural substrates
phosphoribosylaminoimidazolecarboxamide formyltransferase
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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natural substrates
GMP synthase (glutamine-hydrolysing)
ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
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natural substrates
guanylate kinase
ATP + GMP = ADP + GDP
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natural substrates
nucleoside-diphosphate kinase
GTP + ADP = GDP + ATP
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natural substrates
ribonucleoside-diphosphate reductase
GDP + reduced thioredoxin = dGDP + oxidized thioredoxin + H2O
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natural substrates, generic
ribonucleoside-triphosphate reductase (thioredoxin)
GDP + reduced thioredoxin = dGDP + oxidized thioredoxin + H2O
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natural substrates, generic
purine nucleosidase
AMP + H2O = D-ribose 5-phosphate + adenine
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natural substrates
AMP nucleosidase
AMP + H2O = D-ribose 5-phosphate + adenine
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natural substrates
xanthine phosphoribosyltransferase
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
adenine phosphoribosyltransferase
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
hypoxanthine phosphoribosyltransferase
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
deoxynucleoside kinase
ATP + inosine = ADP + IMP
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natural substrates
adenosine kinase
ATP + inosine = ADP + IMP
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natural substrates
inosine kinase
ATP + inosine = ADP + IMP
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natural substrates
2'-deoxyadenosine kinase
ATP + inosine = ADP + IMP
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natural substrates
broad specificity nucleoside kinase
ATP + inosine = ADP + IMP
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natural substrates
xanthine phosphoribosyltransferase
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
adenine phosphoribosyltransferase
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
hypoxanthine phosphoribosyltransferase
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
xanthine phosphoribosyltransferase
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
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natural substrates
adenine phosphoribosyltransferase
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
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-
natural substrates
hypoxanthine phosphoribosyltransferase
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
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-
natural substrates
xanthine phosphoribosyltransferase
5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate
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natural substrates
adenine phosphoribosyltransferase
5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate
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-
natural substrates
hypoxanthine phosphoribosyltransferase
5-phospho-alpha-D-ribose 1-diphosphate + guanine = GMP + diphosphate
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-
natural substrates
deoxyguanosine kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
deoxynucleoside kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
thymidine kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
inosine kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
2'-deoxyadenosine kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
broad specificity nucleoside kinase
guanosine + ATP = guanosine 5'-phosphate + ADP
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natural substrates
chaperonin ATPase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
alkaline phosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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-
natural substrates
glucose-1-phosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
FMN hydrolase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
acid phosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
4-phytase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
5'-nucleotidase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
3'-nucleotidase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
3-phytase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
5'-deoxynucleotidase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
exopolyphosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
NAD+ diphosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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-
natural substrates
UDP-sugar diphosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
apyrase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
nucleotide diphosphatase
adenosine monophosphate + H2O = adenosine + phosphate
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natural substrates
6-phosphofructokinase
ATP + adenosine = ADP + AMP
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natural substrates
deoxynucleoside kinase
ATP + adenosine = ADP + AMP
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natural substrates
adenosine kinase
ATP + adenosine = ADP + AMP
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natural substrates
deoxycytidine kinase
ATP + adenosine = ADP + AMP
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natural substrates
2'-deoxyadenosine kinase
ATP + adenosine = ADP + AMP
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natural substrates
broad specificity nucleoside kinase
ATP + adenosine = ADP + AMP
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natural substrates
purine nucleosidase
adenosine + H2O = D-ribose + adenine
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-
natural substrates
methylthioadenosine nucleosidase
adenosine + H2O = D-ribose + adenine
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natural substrates
inosine nucleosidase
adenosine + H2O = D-ribose + adenine
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natural substrates
rRNA N-glycosylase
adenosine + H2O = D-ribose + adenine
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natural substrates
aminodeoxyfutalosine nucleosidase
adenosine + H2O = D-ribose + adenine
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natural substrates
adenosine nucleosidase
adenosine + H2O = D-ribose + adenine
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natural substrates
ribosylpyrimidine nucleosidase
adenosine + H2O = D-ribose + adenine
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-
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-
natural substrates
adenosylhomocysteine nucleosidase
adenosine + H2O = D-ribose + adenine
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natural substrates
GMP reductase
IMP + NH3 + NADP+ = GMP + NADPH + H+
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natural substrates
dGTPase
dGTP + H2O = deoxyguanosine + triphosphate
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natural substrates
adenylate cyclase
GTP = 3',5'-cyclic GMP + diphosphate
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natural substrates
guanylate cyclase
GTP = 3',5'-cyclic GMP + diphosphate
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natural substrates
ribonucleoside-triphosphate reductase (thioredoxin)
GTP + reduced thioredoxin = dGTP + oxidized thioredoxin + H2O
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natural substrates
deoxycytidine kinase
NTP + deoxyguanosine = NDP + dGMP
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generic
deoxyguanosine kinase
ATP + deoxyguanosine = ADP + dGMP
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natural substrates
deoxynucleoside kinase
ATP + deoxyguanosine = ADP + dGMP
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natural substrates
adenosine kinase
ATP + deoxyguanosine = ADP + dGMP
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natural substrates
deoxycytidine kinase
ATP + deoxyguanosine = ADP + dGMP
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natural substrates
2'-deoxyadenosine kinase
ATP + deoxyguanosine = ADP + dGMP
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-
-
-
natural substrates
AMP phosphorylase
AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate
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-
-
-
natural substrates
ribose 1,5-bisphosphate isomerase
alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate
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-
-
-
natural substrates
ribulose-bisphosphate carboxylase
2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O
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-
-
: multi-step reaction (isomerization, carboxylation, hydration and cleavage)
natural substrates, multi-step reaction
7-methylxanthine demethylase
7-methylxanthine + O2 + NADPH + H+ = xanthine + NADP+ + H2O + formaldehyde
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-
-
-
natural substrates
7-methylxanthine demethylase
caffeine + O2 + NADPH + H+ = theobromine + NADP+ + H2O + formaldehyde
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-
-
-
natural substrates
methylxanthine N1-demethylase
caffeine + O2 + NADPH + H+ = theobromine + NADP+ + H2O + formaldehyde
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natural substrates
7-methylxanthine demethylase
paraxanthine + O2 + NADPH + H+ = 7-methylxanthine + NADP+ + H2O + formaldehyde
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natural substrates
methylxanthine N1-demethylase
paraxanthine + O2 + NADPH + H+ = 7-methylxanthine + NADP+ + H2O + formaldehyde
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natural substrates