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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
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EC Number
Reaction IDs
Stoichiometry Check  
N1-acetylpolyamine oxidase
N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamidopropanal + H2O2
: A flavoprotein (FAD). This enzyme, encoded by the G-11042 gene, is found in mammalian peroxisomes and oxidizes N(1)-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming CPD-10687. Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion. The enzyme also catalyzes the reaction: RXN-10460 [12477380]. The enzyme has no or very weak activity with SPERMINE or SPERMIDINE in absence of aldehydes. However, in presence of aldehydes the enzyme also catalyzes the reactions: |FRAME:RXN-9015| and (with weak efficiency) RXN-12089 [15611107].