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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
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  • EC Number
  • Reaction
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  • Stoichiometry Check
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EC Number
Reaction IDs
Stoichiometry Check  
chalcone isomerase
4,2',4'-trihydroxychalcone = (2S)-4',7-dihydroxyflavanone
: chalcone isomerase
: Functional and structural studies have indicated that chalcone isomerase, catalyzing the first step towards isoflavonoids, accelerates the stereochemically defined intramolecular cyclization of chalcones into biologically active (2S)-flavanones by selectively binding an ionized chalcone in a conformation conducive to ring closure in a diffusion-controlled reaction.