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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.
 

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
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EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Commentary
SPONTANEOUS
N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldoxime + CO2 + H2O
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: the last step of three-step reaction (see R09578, R09579+R09580+R09581)
: A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-phenylalanine, the first committed steps in the biosynthesis of benzylglucosinolate. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is extremely labile and dehydrates spontaneously.The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-phenylacetaldoxime, undergoes a spontaneous isomerization to the (Z) form. The overall reaction is RXN-4602 It can be described by the following sub-reactions: RXN-12066 RXN-12067 RXN-12068 (spontaneous)
phenylalanine N-monooxygenase
N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldoxime + CO2 + H2O
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: the last step of three-step reaction (see R09578, R09579+R09580+R09581)
: A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-phenylalanine, the first committed steps in the biosynthesis of benzylglucosinolate. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is extremely labile and dehydrates spontaneously.The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-phenylacetaldoxime, undergoes a spontaneous isomerization to the (Z) form. The overall reaction is RXN-4602 It can be described by the following sub-reactions: RXN-12066 RXN-12067 RXN-12068 (spontaneous)