New release (2023.1) online!
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BKMS-react is an integrated and non-redundant biochemical reaction database containing known enzyme-catalyzed and spontaneous reactions. Biochemical reactions collected from BRENDA, KEGG, MetaCyc and SABIO-RK were matched and integrated by aligning substrates and products.

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
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  • EC Number
  • Reaction
  • Pathways
  • Reaction IDs
  • Stoichiometry Check
  • Missing Substrate
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  • Commentary
  • Remark
EC Number
Reaction IDs
Stoichiometry Check  
formyltetrahydrofolate deformylase
10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
: This reaction produces formate from formyl-THF, providing the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. It may also play a role in regulating the 1-carbon pool.