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BRENDA KEGG MetaCyc

vitamin B12 metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences2.1.1.131 precorrin-3B C17-methyltransferase S-Adenosyl-L-methionine + Precorrin 3B <=> S-Adenosyl-L-homocysteine + Precorrin 4 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)   R05180 show the reaction diagram 2.1.1.131-RXN show the reaction diagram  
show all sequences2.1.1.131 precorrin-3B C17-methyltransferase S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 vitamin B12 metabolism     BR1454 show the reaction diagram      
show all sequences2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating) 2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
  BR1455 show the reaction diagram R05149 show the reaction diagram 2.1.1.132-RXN show the reaction diagram  
show all sequences2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase cobalt-precorrin-7 + S-adenosyl-L-methionine = cobalt-precorrin-8 + S-adenosyl-L-homocysteine vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR50788 show the reaction diagram R07775 show the reaction diagram RXN-8767 show the reaction diagram  
show all sequences1.16.8.1 cob(II)yrinic acid a,c-diamide reductase 2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR47984 show the reaction diagram R05218 show the reaction diagram R343-RXN show the reaction diagram  
show all sequences6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR48014 show the reaction diagram R05224 show the reaction diagram R341-RXN show the reaction diagram  
show all sequences6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing) 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR48011 show the reaction diagram R05225 show the reaction diagram R345-RXN show the reaction diagram  
    S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BS375288 show the reaction diagram R05809 show the reaction diagram RXN-8761 show the reaction diagram  
show all sequences2.1.1.131 precorrin-3B C17-methyltransferase S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BS375288 show the reaction diagram R05809 show the reaction diagram RXN-8761 show the reaction diagram  
show all sequences2.1.1.271 cobalt-precorrin-4 methyltransferase Cobalt-precorrin 4 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 5A + S-Adenosyl-L-homocysteine vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR50534 show the reaction diagram R05810 show the reaction diagram RXN-8762 show the reaction diagram  
show all sequences2.4.2.21 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin salvage from cobinamide II,
adenosylcobalamin salvage from cobinamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR44272 show the reaction diagram R04148 show the reaction diagram DMBPPRIBOSYLTRANS-RXN show the reaction diagram  
show all sequences2.1.1.196 cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating] cobalt-precorrin-6B + S-adenosyl-L-methionine + H+ = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR49386 show the reaction diagram R07774 show the reaction diagram RXN-8766 show the reaction diagram  
show all sequences2.1.1.195 cobalt-precorrin-5B (C1)-methyltransferase cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR49385 show the reaction diagram R07773 show the reaction diagram RXN-8764 show the reaction diagram  
show all sequences1.3.1.106 cobalt-precorrin-6A reductase cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR50935 show the reaction diagram R05812 show the reaction diagram RXN-8765 show the reaction diagram  
show all sequences2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin salvage from cobinamide II,
adenosylcobalamin salvage from cobinamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR47996 show the reaction diagram R05222 show the reaction diagram COBINPGUANYLYLTRANS-RXN show the reaction diagram  
show all sequences6.3.1.10 adenosylcobinamide-phosphate synthase ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin salvage from cobinamide II,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR48012 show the reaction diagram R06529 show the reaction diagram RXN-6261 show the reaction diagram  
show all sequences1.3.1.54 precorrin-6A reductase precorrin-6B + NADP+ = precorrin-6A + NADPH + H+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR1202 show the reaction diagram R05150 show the reaction diagram 1.3.1.54-RXN show the reaction diagram  
show all sequences2.7.8.26 adenosylcobinamide-GDP ribazoletransferase adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate = GMP + adenosylcobalamin 5'-phosphate vitamin B12 metabolism   adenosylcobalamin salvage from cobinamide II,
adenosylcobalamin salvage from cobinamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I
BS370846 show the reaction diagram R11174 show the reaction diagram COBALAMIN5PSYN-RXN show the reaction diagram  
show all sequences4.99.1.3 sirohydrochlorin cobaltochelatase cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR48008 show the reaction diagram R05807 show the reaction diagram 4.99.1.3-RXN show the reaction diagram  
show all sequences2.7.8.26 adenosylcobinamide-GDP ribazoletransferase adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II BR47998 show the reaction diagram R05223 show the reaction diagram COBALAMINSYN-RXN show the reaction diagram  
show all sequences3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II BR47999 show the reaction diagram R04594 show the reaction diagram RIBAZOLEPHOSPHAT-RXN show the reaction diagram,
RXN-16788 show the reaction diagram
 
show all sequences2.1.1.151 cobalt-factor II C20-methyltransferase S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR47994 show the reaction diagram R05808 show the reaction diagram 2.1.1.151-RXN show the reaction diagram  
show all sequences1.14.99.40 5,6-dimethylbenzimidazole synthase FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product vitamin B12 metabolism     BR51095 show the reaction diagram      
show all sequences1.13.11.79 5,6-dimethylbenzimidazole synthase FMNH2 + oxygen = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate vitamin B12 metabolism   5,6-dimethylbenzimidazole biosynthesis I (aerobic),
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
    RXN-8771 show the reaction diagram  
1.5.1.-   FMNH2 + NADP+ = FMN + NADPH + H+ vitamin B12 metabolism Riboflavin metabolism,
Metabolic pathways
5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
BR36899 show the reaction diagram R05706 show the reaction diagram FMNREDUCT-RXN show the reaction diagram,
RXN-12444 show the reaction diagram
5302
show all sequences1.5.1.30 flavin reductase (NADPH) FMNH2 + NADP+ = FMN + NADPH + H+ vitamin B12 metabolism Riboflavin metabolism,
Metabolic pathways
5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
BR36899 show the reaction diagram R05706 show the reaction diagram FMNREDUCT-RXN show the reaction diagram,
RXN-12444 show the reaction diagram
5302
show all sequences1.5.1.38 FMN reductase (NADPH) FMNH2 + NADP+ = FMN + NADPH + H+ vitamin B12 metabolism Riboflavin metabolism,
Metabolic pathways
5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
BR36899 show the reaction diagram R05706 show the reaction diagram FMNREDUCT-RXN show the reaction diagram,
RXN-12444 show the reaction diagram
5302
show all sequences1.5.1.39 FMN reductase [NAD(P)H] FMNH2 + NADP+ = FMN + NADPH + H+ vitamin B12 metabolism Riboflavin metabolism,
Metabolic pathways
5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
BR36899 show the reaction diagram R05706 show the reaction diagram FMNREDUCT-RXN show the reaction diagram,
RXN-12444 show the reaction diagram
5302
show all sequences3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase adenosylcobalamin 5'-phosphate + H2O = coenzyme B12 + phosphate vitamin B12 metabolism   adenosylcobalamin salvage from cobinamide II,
adenosylcobalamin salvage from cobinamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I
BR49541 show the reaction diagram R11173 show the reaction diagram RXN-8770 show the reaction diagram  
show all sequences5.4.99.60 cobalt-precorrin-8 methylmutase cobalt-precorrin-8 = cobyrinate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR51009 show the reaction diagram R05814 show the reaction diagram RXN-8768 show the reaction diagram  
show all sequences1.14.13.83 precorrin-3B synthase Precorrin 3A + Oxygen + NADH + H+ <=> Precorrin 3B + NAD+ + H2O vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)   R05217 show the reaction diagram R321-RXN show the reaction diagram  
show all sequences1.14.13.83 precorrin-3B synthase precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O vitamin B12 metabolism     BR47982 show the reaction diagram      
show all sequences2.1.1.152 precorrin-6A synthase (deacetylating) S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR47993 show the reaction diagram R05219 show the reaction diagram R322-RXN show the reaction diagram  
show all sequences3.7.1.12 cobalt-precorrin 5A hydrolase cobalt-precorrin-5A + H2O = cobalt-precorrin-5B + acetaldehyde + 2 H+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR49393 show the reaction diagram R07772 show the reaction diagram RXN-8763 show the reaction diagram  
show all sequences5.4.99.61 precorrin-8X methylmutase Precorrin-8X = hydrogenobyrinate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR16 show the reaction diagram R05177 show the reaction diagram 5.4.1.2-RXN show the reaction diagram  
show all sequences2.5.1.17 cob(I)yrinic acid a,c-diamide adenosyltransferase ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I,
adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II
BR48626 show the reaction diagram R05220 show the reaction diagram R344-RXN show the reaction diagram  
show all sequences2.1.1.130 precorrin-2 C20-methyltransferase S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A + H+ vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR1453 show the reaction diagram R03948 show the reaction diagram 2.1.1.130-RXN show the reaction diagram  
show all sequences6.3.5.11 cobyrinate a,c-diamide synthase 2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR49510 show the reaction diagram R05815 show the reaction diagram RXN-8769 show the reaction diagram 6681
    2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) BR49510 show the reaction diagram R05815 show the reaction diagram RXN-8769 show the reaction diagram 6681
show all sequences6.6.1.2 cobaltochelatase ATP + hydrogenobyrinic acid a,c-diamide + Co2+ + H2O = ADP + phosphate + cob(II)yrinic acid a,c-diamide vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR48015 show the reaction diagram R05227 show the reaction diagram R342-RXN show the reaction diagram  
show all sequences2.1.1.133 precorrin-4 C11-methyltransferase S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR6348 show the reaction diagram R05181 show the reaction diagram 2.1.1.133-RXN show the reaction diagram  
show all sequences2.1.1.271 cobalt-precorrin-4 methyltransferase S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5 vitamin B12 metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) BR6348 show the reaction diagram R05181 show the reaction diagram 2.1.1.133-RXN show the reaction diagram