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BRENDA KEGG MetaCyc

androgen and estrogen metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
androstenedione degradation BR49990 show the reaction diagram R09883 show the reaction diagram RXN-12718 show the reaction diagram  
show all sequences1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione BR29275 show the reaction diagram R01836 show the reaction diagram 1.1.1.51-RXN_WOP show the reaction diagram,
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN show the reaction diagram
1915
show all sequences1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione BR29275 show the reaction diagram R01836 show the reaction diagram 1.1.1.51-RXN_WOP show the reaction diagram,
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN show the reaction diagram
1915
show all sequences1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione BR29275 show the reaction diagram R01836 show the reaction diagram 1.1.1.51-RXN_WOP show the reaction diagram,
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN show the reaction diagram
1915
show all sequences1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione BR29275 show the reaction diagram R01836 show the reaction diagram 1.1.1.51-RXN_WOP show the reaction diagram,
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN show the reaction diagram
1915
show all sequences1.1.1.62 17beta-estradiol 17-dehydrogenase testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione BR29275 show the reaction diagram R01836 show the reaction diagram 1.1.1.51-RXN_WOP show the reaction diagram,
TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN show the reaction diagram
1915
show all sequences1.14.14.32 17alpha-hydroxyprogesterone deacetylase 17-alpha-hydroxyprogesterone + reduced [NADPH-hemoprotein reductase] + oxygen = androst-4-ene-3,17-dione + acetate + oxidized [NADPH-hemoprotein reductase] + H2O + H+ androgen and estrogen metabolism         4.1.2.30-RXN show the reaction diagram  
show all sequences1.14.14.32 17alpha-hydroxyprogesterone deacetylase 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O androgen and estrogen metabolism Steroid hormone biosynthesis   BR362 show the reaction diagram R08518 show the reaction diagram    
SPONTANEOUS   9alpha-Hydroxyandrosta-1,4-diene-3,17-dione <=> 3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
androstenedione degradation   R09885 show the reaction diagram RXN-12715 show the reaction diagram  
show all sequences1.1.1.184 carbonyl reductase (NADPH) testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.2 alcohol dehydrogenase (NADP+) testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.62 17beta-estradiol 17-dehydrogenase testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.64 testosterone 17beta-dehydrogenase (NADP+) testosterone + NADP+ = androstenedione + NADPH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
testosterone and androsterone degradation to androstendione,
androgen biosynthesis
BR29315 show the reaction diagram,
BS438469 show the reaction diagram
R01838 show the reaction diagram 1.1.1.51-RXN show the reaction diagram,
1.1.1.64-RXN show the reaction diagram
1917
show all sequences1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase testosterone + NADPH + H+ = DELTA4-androstene-3,17-dione + NADP+ androgen and estrogen metabolism     BS425050 show the reaction diagram      
show all sequences4.1.3.43 4-hydroxy-2-oxohexanoate aldolase (S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate androgen and estrogen metabolism   4-nitrotoluene degradation II,
androstenedione degradation
BR50714 show the reaction diagram   RXN-12735 show the reaction diagram  
show all sequences1.14.13.142 3-ketosteroid 9alpha-monooxygenase androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
androstenedione degradation BR49974 show the reaction diagram R09860 show the reaction diagram RXN-12691 show the reaction diagram  
show all sequences1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O androgen and estrogen metabolism     BR29153 show the reaction diagram R02724 show the reaction diagram 1.14.15.6-RXN show the reaction diagram  
show all sequences1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin androgen and estrogen metabolism     BS386399 show the reaction diagram      
show all sequences4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = (S)-4-hydroxy-2-oxohexanoate androgen and estrogen metabolism   androstenedione degradation     RXN-12734 show the reaction diagram  
show all sequences1.2.1.10 acetaldehyde dehydrogenase (acetylating) propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ androgen and estrogen metabolism Xylene degradation,
Propanoate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
L-1,2-propanediol degradation,
androstenedione degradation
BR50602 show the reaction diagram R09097 show the reaction diagram RXN-12736 show the reaction diagram 10853
show all sequences1.2.1.57 butanal dehydrogenase propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ androgen and estrogen metabolism Xylene degradation,
Propanoate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
L-1,2-propanediol degradation,
androstenedione degradation
BR50602 show the reaction diagram R09097 show the reaction diagram RXN-12736 show the reaction diagram 10853
show all sequences1.2.1.87 propanal dehydrogenase (CoA-propanoylating) propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ androgen and estrogen metabolism Xylene degradation,
Propanoate metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
L-1,2-propanediol degradation,
androstenedione degradation
BR50602 show the reaction diagram R09097 show the reaction diagram RXN-12736 show the reaction diagram 10853
show all sequences6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
androstenedione degradation BR51067 show the reaction diagram R10769 show the reaction diagram RXN-12746 show the reaction diagram  
    pregnenolone + NAD+ = progesterone + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Metabolic pathways
  BS383305 show the reaction diagram R02216 show the reaction diagram RXN-9722 show the reaction diagram 2188
show all sequences1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase pregnenolone + NAD+ = progesterone + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Metabolic pathways
  BS383305 show the reaction diagram R02216 show the reaction diagram RXN-9722 show the reaction diagram 2188
show all sequences1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase pregnenolone + NAD+ = progesterone + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Metabolic pathways
  BS383305 show the reaction diagram R02216 show the reaction diagram RXN-9722 show the reaction diagram 2188
show all sequences5.3.3.1 steroid DELTA-isomerase pregnenolone + NAD+ = progesterone + NADH + H+ androgen and estrogen metabolism Steroid hormone biosynthesis,
Metabolic pathways
  BS383305 show the reaction diagram R02216 show the reaction diagram RXN-9722 show the reaction diagram 2188
show all sequences1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase pregnenolone + NADH + H+ = progesterone + NAD+ androgen and estrogen metabolism     BS426945 show the reaction diagram      
show all sequences1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments,
Degradation of aromatic compounds
androstenedione degradation BR40480 show the reaction diagram R04597 show the reaction diagram 1.13.11.25-RXN show the reaction diagram  
show all sequences1.14.14.12 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O androgen and estrogen metabolism Steroid degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
androstenedione degradation BR49866 show the reaction diagram R09819 show the reaction diagram RXN-12717 show the reaction diagram