Pathways

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BRENDA KEGG MetaCyc

arachidonic acid metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences1.14.99.1 prostaglandin-endoperoxide synthase arachidonate + electron donor + O2 = prostaglandin H2 + oxidized electron donor + H2O arachidonic acid metabolism     BS287970 show the reaction diagram      
show all sequences5.3.99.3 prostaglandin-E synthase (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
C20 prostanoid biosynthesis BR48832 show the reaction diagram R02265 show the reaction diagram PROSTAGLANDIN-E-SYNTHASE-RXN show the reaction diagram 2232
show all sequences1.11.1.9 glutathione peroxidase 5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O arachidonic acid metabolism     BS261217 show the reaction diagram      
show all sequences5.3.99.3 prostaglandin-E synthase 5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O arachidonic acid metabolism     BS261217 show the reaction diagram      
show all sequences5.3.99.2 Prostaglandin-D synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
C20 prostanoid biosynthesis BR9 show the reaction diagram R02266 show the reaction diagram PROSTAGLANDIN-D-SYNTHASE-RXN show the reaction diagram 2233
show all sequences5.3.99.3 prostaglandin-E synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
C20 prostanoid biosynthesis BR9 show the reaction diagram R02266 show the reaction diagram PROSTAGLANDIN-D-SYNTHASE-RXN show the reaction diagram 2233
show all sequences3.4.19.14 leukotriene-C4 hydrolase leukotriene C4 + H2O = leukotriene D4 + L-glutamate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BR49989 show the reaction diagram R09875 show the reaction diagram RXN-12825 show the reaction diagram  
show all sequences1.1.1.184 carbonyl reductase (NADPH) (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BR36706 show the reaction diagram R02581 show the reaction diagram PROSTAGLANDIN-E2-9-REDUCTASE-RXN show the reaction diagram 2488
show all sequences1.1.1.189 prostaglandin-E2 9-reductase (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BR36706 show the reaction diagram R02581 show the reaction diagram PROSTAGLANDIN-E2-9-REDUCTASE-RXN show the reaction diagram 2488
show all sequences1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+) prostaglandin E2 + NADP+ = prostaglandin F2alpha + NADPH arachidonic acid metabolism     BS230461 show the reaction diagram      
show all sequences1.13.11.40 arachidonate 8-lipoxygenase arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate arachidonic acid metabolism Arachidonic acid metabolism   BR40471 show the reaction diagram R01594 show the reaction diagram    
show all sequences3.4.13.19 membrane dipeptidase leukotriene D4 + H2O = leukotriene E4 arachidonic acid metabolism     BS392478 show the reaction diagram      
show all sequences4.4.1.20 leukotriene-C4 synthase leukotriene C4 = leukotriene A4 + glutathione arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
leukotriene biosynthesis BR48007 show the reaction diagram R03059 show the reaction diagram LEUKOTRIENE-C4-SYNTHASE-RXN show the reaction diagram 8569
show all sequences1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+ arachidonic acid metabolism     BS230452 show the reaction diagram      
show all sequences1.1.1.231 15-hydroxyprostaglandin-I dehydrogenase (NADP+) prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+ arachidonic acid metabolism     BS230452 show the reaction diagram      
show all sequences5.3.99.4 prostaglandin-I synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
C20 prostanoid biosynthesis BR6442 show the reaction diagram R02267 show the reaction diagram PROSTAGLANDIN-I-SYNTHASE-RXN show the reaction diagram  
show all sequences1.13.11.31 arachidonate 12-lipoxygenase arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BR37067 show the reaction diagram R01596 show the reaction diagram ARACHIDONATE-12-LIPOXYGENASE-RXN show the reaction diagram 1745
show all sequences1.1.1.188 prostaglandin-F synthase prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+ arachidonic acid metabolism Arachidonic acid metabolism   BS371126 show the reaction diagram R02799 show the reaction diagram   7733
show all sequences1.1.1.62 17beta-estradiol 17-dehydrogenase prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+ arachidonic acid metabolism Arachidonic acid metabolism   BS371126 show the reaction diagram R02799 show the reaction diagram   7733
show all sequences1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+ arachidonic acid metabolism Arachidonic acid metabolism   BS371126 show the reaction diagram R02799 show the reaction diagram   7733
show all sequences3.3.2.10 soluble epoxide hydrolase (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BS403051 show the reaction diagram R07109 show the reaction diagram    
show all sequences3.3.2.9 microsomal epoxide hydrolase (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BS403051 show the reaction diagram R07109 show the reaction diagram    
show all sequences1.1.1.232 15-hydroxyicosatetraenoate dehydrogenase (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NADP+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NADPH + H+ arachidonic acid metabolism Arachidonic acid metabolism   BR29270 show the reaction diagram R04518 show the reaction diagram 1.1.1.232-RXN show the reaction diagram  
show all sequences3.3.2.7 hepoxilin-epoxide hydrolase (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate arachidonic acid metabolism     BR48210 show the reaction diagram R04609 show the reaction diagram HEPOXILIN-EPOXIDE-HYDROLASE-RXN show the reaction diagram  
show all sequences1.13.11.33 arachidonate 15-lipoxygenase arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate arachidonic acid metabolism Arachidonic acid metabolism,
Metabolic pathways
  BR47601 show the reaction diagram R01593 show the reaction diagram ARACHIDONATE-15-LIPOXYGENASE-RXN show the reaction diagram 1742
show all sequences1.11.1.9 glutathione peroxidase 2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O arachidonic acid metabolism Arachidonic acid metabolism     R07035 show the reaction diagram