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BRENDA KEGG MetaCyc

heme metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences4.2.1.75 uroporphyrinogen-III synthase hydroxymethylbilane = uroporphyrinogen III + H2O heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
tetrapyrrole biosynthesis II (from glycine),
tetrapyrrole biosynthesis I (from glutamate)
BR452 show the reaction diagram,
BS2108 show the reaction diagram
R03165 show the reaction diagram UROGENIIISYN-RXN show the reaction diagram  
show all sequences4.99.1.1 protoporphyrin ferrochelatase protoheme + 2 H+ = protoporphyrin + Fe2+ heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
superpathway of heme b biosynthesis from uroporphyrinogen-III,
heme b biosynthesis II (anaerobic),
heme b biosynthesis I (aerobic)
BR3454 show the reaction diagram R00310 show the reaction diagram PROTOHEMEFERROCHELAT-RXN show the reaction diagram 802
show all sequences1.3.1.24 biliverdin reductase biliverdin IXalpha + NADPH + H+ = bilirubin IXalpha + NADP+ heme metabolism   heme degradation I BS396611 show the reaction diagram   BILIVERDIN-REDUCTASE-RXN show the reaction diagram  
show all sequences1.3.1.24 biliverdin reductase bilirubin + NADP+ = biliverdin + NADPH + H+ heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
  BR40361 show the reaction diagram R02393 show the reaction diagram   2334
show all sequences1.3.1.76 precorrin-2 dehydrogenase precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+ heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion),
siroheme biosynthesis
BR47985 show the reaction diagram R03947 show the reaction diagram DIMETHUROPORDEHYDROG-RXN show the reaction diagram  
show all sequences1.3.98.3 coproporphyrinogen dehydrogenase coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic),
heme b biosynthesis II (anaerobic)
BR48612 show the reaction diagram R06895 show the reaction diagram HEMN-RXN show the reaction diagram  
show all sequences2.5.1.61 hydroxymethylbilane synthase 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
tetrapyrrole biosynthesis II (from glycine),
tetrapyrrole biosynthesis I (from glutamate)
BR44288 show the reaction diagram R00084 show the reaction diagram OHMETHYLBILANESYN-RXN show the reaction diagram 669
show all sequences1.2.1.70 glutamyl-tRNA reductase L-Glutamyl-tRNA(Glu) + NADPH + H+ <=> (S)-4-Amino-5-oxopentanoate + tRNA(Glu) + NADP+ heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
    R04109 show the reaction diagram    
show all sequences1.2.1.70 glutamyl-tRNA reductase L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+ heme metabolism     BR48497 show the reaction diagram      
show all sequences1.3.5.3 protoporphyrinogen IX dehydrogenase (menaquinone) protoporphyrinogen IX + 3 menaquinone = protoporphyrin IX + 3 menaquinol heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
  BR49166 show the reaction diagram R09489 show the reaction diagram    
show all sequences4.99.1.4 sirohydrochlorin ferrochelatase siroheme + 2 H+ = sirohydrochlorin + Fe2+ heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
siroheme biosynthesis BR48009 show the reaction diagram R02864 show the reaction diagram SIROHEME-FERROCHELAT-RXN show the reaction diagram  
show all sequences4.1.1.37 uroporphyrinogen decarboxylase uroporphyrinogen III = coproporphyrinogen III + 4 CO2 heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
heme b biosynthesis IV (Gram-positive bacteria),
3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent),
3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent),
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic),
superpathway of heme b biosynthesis from uroporphyrinogen-III,
heme b biosynthesis II (anaerobic),
heme b biosynthesis I (aerobic)
BR296 show the reaction diagram R03197 show the reaction diagram UROGENDECARBOX-RXN show the reaction diagram  
4.1.1.-   siroheme + H+ = 12,18-didecarboxysiroheme + CO2 heme metabolism   heme b biosynthesis III (from siroheme),
heme d1 biosynthesis
    RXN-15805 show the reaction diagram  
show all sequences4.1.1.B11 siroheme decarboxylase siroheme = 12,18-didecarboxysiroheme + 2 CO2 heme metabolism     BR51140 show the reaction diagram      
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2 heme metabolism   factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation),
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion),
siroheme biosynthesis
BR49530 show the reaction diagram R07238 show the reaction diagram RXN-8675 show the reaction diagram  
show all sequences2.1.1.107 uroporphyrinogen-III C-methyltransferase S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2 heme metabolism   factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation),
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion),
siroheme biosynthesis
BR49530 show the reaction diagram R07238 show the reaction diagram RXN-8675 show the reaction diagram  
show all sequences2.1.1.107 uroporphyrinogen-III C-methyltransferase S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1 heme metabolism   factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation),
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion),
siroheme biosynthesis
BR43866 show the reaction diagram R07237 show the reaction diagram UROPORIIIMETHYLTRANSA-RXN show the reaction diagram  
    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1 heme metabolism   factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation),
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion),
siroheme biosynthesis
BR43866 show the reaction diagram R07237 show the reaction diagram UROPORIIIMETHYLTRANSA-RXN show the reaction diagram  
show all sequences4.2.1.24 porphobilinogen synthase 2 5-aminolevulinate = porphobilinogen + 2 H2O heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
tetrapyrrole biosynthesis II (from glycine),
tetrapyrrole biosynthesis I (from glutamate)
BR22826 show the reaction diagram R00036 show the reaction diagram PORPHOBILSYNTH-RXN show the reaction diagram  
show all sequences5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase L-glutamate 1-semialdehyde = 5-aminolevulinate heme metabolism Porphyrin and chlorophyll metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments
tetrapyrrole biosynthesis I (from glutamate) BR32 show the reaction diagram R02272 show the reaction diagram GSAAMINOTRANS-RXN show the reaction diagram