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BRENDA KEGG MetaCyc

lipid A biosynthesis (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences2.4.1.B64 glucosyltransferase Waag UDP-alpha-D-glucose + alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = UDP + beta-D-glucosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose lipid A biosynthesis     BR51116 show the reaction diagram      
2.4.-.-   alpha-D-Kdo-(2rarr4)-alpha-D-Kdo-(2rarr6)-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl-Kdo2-lipid A + ADP + H+ lipid A biosynthesis   Lipid A-core biosynthesis     RXN0-5118 show the reaction diagram  
show all sequences2.3.1.191 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein] lipid A biosynthesis Lipopolysaccharide biosynthesis,
Metabolic pathways
lipid IVA biosynthesis BR49174 show the reaction diagram R04550 show the reaction diagram UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN show the reaction diagram  
show all sequences2.7.1.130 tetraacyldisaccharide 4'-kinase ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} lipid A biosynthesis Lipopolysaccharide biosynthesis,
Metabolic pathways
lipid IVA biosynthesis BR47743 show the reaction diagram R04657 show the reaction diagram TETRAACYLDISACC4KIN-RXN show the reaction diagram  
1.1.1.-   alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.1 alcohol dehydrogenase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.10 L-xylulose reductase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.149 20alpha-hydroxysteroid dehydrogenase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.156 glycerol 2-dehydrogenase (NADP+) alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.184 carbonyl reductase (NADPH) alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.188 prostaglandin-F synthase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.19 glucuronate reductase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.2 alcohol dehydrogenase (NADP+) alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.21 aldehyde reductase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.265 3-methylbutanal reductase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.372 D/L-glyceraldehyde reductase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.1.1.72 glycerol dehydrogenase (NADP+) alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase alditol + NADP+ = aldose + NADPH + H+ lipid A biosynthesis,
degradation of sugar acids
Glycerolipid metabolism,
Pentose and glucuronate interconversions,
Metabolic pathways
D-galacturonate degradation III,
cytidine-5'-diphosphate-glycerol biosynthesis
BR29253 show the reaction diagram,
BR29334 show the reaction diagram,
BR51021 show the reaction diagram,
BS165086 show the reaction diagram,
BS397078_WOP show the reaction diagram
R01041 show the reaction diagram,
R02820 show the reaction diagram,
R10563 show the reaction diagram
ALDEHYDE-REDUCTASE-RXN show the reaction diagram,
GLYCEROL-DEHYDROGENASE-NADP+-RXN show the reaction diagram,
RXN-11382 show the reaction diagram,
RXN-11709 show the reaction diagram
10025,
222,
395,
6749
show all sequences3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine + H2O = UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + acetate lipid A biosynthesis Lipopolysaccharide biosynthesis,
Metabolic pathways
lipid IVA biosynthesis BR49202 show the reaction diagram R04587 show the reaction diagram UDPACYLGLCNACDEACETYL-RXN show the reaction diagram  
show all sequences3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O = 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP lipid A biosynthesis     BS402961 show the reaction diagram      
show all sequences2.4.1.182 lipid-A-disaccharide synthase UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate lipid A biosynthesis     BS422082 show the reaction diagram      
1.1.1.-   alditol + NAD+ = aldose + NADH + H+ lipid A biosynthesis   cytidine-5'-diphosphate-glycerol biosynthesis BR29253_WOP show the reaction diagram,
BS139563 show the reaction diagram
R02819 show the reaction diagram ALDEHYDE-REDUCTASE-RXN_WOP show the reaction diagram,
RXN-11709_WOP show the reaction diagram
6774
show all sequences1.1.1.2 alcohol dehydrogenase (NADP+) alditol + NAD+ = aldose + NADH + H+ lipid A biosynthesis   cytidine-5'-diphosphate-glycerol biosynthesis BR29253_WOP show the reaction diagram,
BS139563 show the reaction diagram
R02819 show the reaction diagram ALDEHYDE-REDUCTASE-RXN_WOP show the reaction diagram,
RXN-11709_WOP show the reaction diagram
6774
show all sequences1.1.1.202 1,3-propanediol dehydrogenase alditol + NAD+ = aldose + NADH + H+ lipid A biosynthesis   cytidine-5'-diphosphate-glycerol biosynthesis BR29253_WOP show the reaction diagram,
BS139563 show the reaction diagram
R02819 show the reaction diagram ALDEHYDE-REDUCTASE-RXN_WOP show the reaction diagram,
RXN-11709_WOP show the reaction diagram
6774
show all sequences1.1.1.21 aldehyde reductase alditol + NAD+ = aldose + NADH + H+ lipid A biosynthesis   cytidine-5'-diphosphate-glycerol biosynthesis BR29253_WOP show the reaction diagram,
BS139563 show the reaction diagram
R02819 show the reaction diagram ALDEHYDE-REDUCTASE-RXN_WOP show the reaction diagram,
RXN-11709_WOP show the reaction diagram
6774
show all sequences1.1.1.78 methylglyoxal reductase (NADH) alditol + NAD+ = aldose + NADH + H+ lipid A biosynthesis   cytidine-5'-diphosphate-glycerol biosynthesis BR29253_WOP show the reaction diagram,
BS139563 show the reaction diagram
R02819 show the reaction diagram ALDEHYDE-REDUCTASE-RXN_WOP show the reaction diagram,
RXN-11709_WOP show the reaction diagram
6774
show all sequences2.3.1.129 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine lipid A biosynthesis Lipopolysaccharide biosynthesis,
Metabolic pathways
lipid IVA biosynthesis BS370322 show the reaction diagram R04567 show the reaction diagram UDPNACETYLGLUCOSAMACYLTRANS-RXN show the reaction diagram