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BRENDA KEGG MetaCyc

tetrahydrofolate metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H] 5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+ tetrahydrofolate metabolism One carbon pool by folate,
Metabolic pathways,
Microbial metabolism in diverse environments
  BR36896 show the reaction diagram R01224 show the reaction diagram   1453
show all sequences6.3.3.2 5-formyltetrahydrofolate cyclo-ligase ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate tetrahydrofolate metabolism     BS638 show the reaction diagram      
show all sequences4.3.99.3 7-carboxy-7-deazaguanine synthase 6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3 tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
preQ0 biosynthesis BR50129 show the reaction diagram R10002 show the reaction diagram RXN0-6575 show the reaction diagram  
show all sequences6.3.2.12 dihydrofolate synthase ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
tetrahydrofolate biosynthesis BR104 show the reaction diagram R02237 show the reaction diagram DIHYDROFOLATESYNTH-RXN show the reaction diagram  
show all sequences6.3.2.17 tetrahydrofolate synthase ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
tetrahydrofolate biosynthesis BR104 show the reaction diagram R02237 show the reaction diagram DIHYDROFOLATESYNTH-RXN show the reaction diagram  
show all sequences3.5.4.16 GTP cyclohydrolase I GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate tetrahydrofolate metabolism   6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
threo-tetrahydrobiopterin biosynthesis,
preQ0 biosynthesis,
erythro-tetrahydrobiopterin biosynthesis II,
erythro-tetrahydrobiopterin biosynthesis I
BR22737 show the reaction diagram R00424 show the reaction diagram GTP-CYCLOHYDRO-I-RXN show the reaction diagram 9177
show all sequences5.1.99.7 dihydroneopterin triphosphate 2'-epimerase 7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate tetrahydrofolate metabolism Folate biosynthesis tetrahydromonapterin biosynthesis BR51427 show the reaction diagram,
BS433336 show the reaction diagram
R11082 show the reaction diagram H2NTPEPIM-RXN show the reaction diagram  
show all sequences5.1.99.8 7,8-dihydroneopterin epimerase 7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate tetrahydrofolate metabolism Folate biosynthesis tetrahydromonapterin biosynthesis BR51427 show the reaction diagram,
BS433336 show the reaction diagram
R11082 show the reaction diagram H2NTPEPIM-RXN show the reaction diagram  
show all sequences3.5.1.10 formyltetrahydrofolate deformylase 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate tetrahydrofolate metabolism Glyoxylate and dicarboxylate metabolism,
One carbon pool by folate
  BR22680 show the reaction diagram R00944 show the reaction diagram   1259
show all sequences1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ tetrahydrofolate metabolism One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
  BR36900 show the reaction diagram R00939 show the reaction diagram   100
show all sequences1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+) 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+ tetrahydrofolate metabolism One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
  BR36900 show the reaction diagram R00939 show the reaction diagram   100
show all sequences2.5.1.15 dihydropteroate synthase (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
tetrahydrofolate biosynthesis BR47663 show the reaction diagram R03067 show the reaction diagram H2PTEROATESYNTH-RXN show the reaction diagram 2910
show all sequences2.6.1.85 aminodeoxychorismate synthase chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate tetrahydrofolate metabolism Folate biosynthesis 4-aminobenzoate biosynthesis BR47979 show the reaction diagram R01716 show the reaction diagram PABASYN-RXN show the reaction diagram 1828
show all sequences1.5.1.50 dihydromonapterin reductase 5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+ tetrahydrofolate metabolism Folate biosynthesis tetrahydromonapterin biosynthesis BR51347 show the reaction diagram R11019 show the reaction diagram RXN0-6367 show the reaction diagram  
show all sequences6.3.4.20 7-cyano-7-deazaguanine synthase 7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
preQ0 biosynthesis BR50022 show the reaction diagram R09978 show the reaction diagram RXN-12093 show the reaction diagram  
show all sequences4.1.3.38 aminodeoxychorismate lyase 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate tetrahydrofolate metabolism Folate biosynthesis 4-aminobenzoate biosynthesis BR47975 show the reaction diagram R05553 show the reaction diagram ADCLY-RXN show the reaction diagram  
show all sequences4.1.2.50 6-carboxytetrahydropterin synthase 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate tetrahydrofolate metabolism Folate biosynthesis,
Metabolic pathways
preQ0 biosynthesis BR50066 show the reaction diagram R09959 show the reaction diagram RXN0-5507 show the reaction diagram