Pathways

Filter results:
BRENDA KEGG MetaCyc

leucine metabolism (BRENDA)

:= amino acid sequences := show the reaction diagram
download this result as tab stop separated values
(Excel, OpenOffice) format
Download as CSV
EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences1.4.1.20 phenylalanine dehydrogenase L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
  BR33798 show the reaction diagram R01088 show the reaction diagram LEUCINE-DEHYDROGENASE-RXN show the reaction diagram 1350
show all sequences1.4.1.8 valine dehydrogenase (NADP+) L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
  BR33798 show the reaction diagram R01088 show the reaction diagram LEUCINE-DEHYDROGENASE-RXN show the reaction diagram 1350
show all sequences1.4.1.9 leucine dehydrogenase L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
  BR33798 show the reaction diagram R01088 show the reaction diagram LEUCINE-DEHYDROGENASE-RXN show the reaction diagram 1350
show all sequences5.4.3.7 leucine 2,3-aminomutase (2S)-alpha-leucine = (3R)-beta-leucine leucine metabolism   L-leucine degradation II BR31 show the reaction diagram,
BS1198 show the reaction diagram
R01091 show the reaction diagram LEUCINE-23-AMINOMUTASE-RXN show the reaction diagram  
    beta-ketoisocaproate + H2O = H+ + isobutanoate + acetate leucine metabolism   L-leucine degradation II     RXN-7691 show the reaction diagram  
show all sequences4.2.1.33 3-isopropylmalate dehydratase (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
BR413 show the reaction diagram,
BR49521 show the reaction diagram,
BS1964 show the reaction diagram
R03968 show the reaction diagram,
R04001 show the reaction diagram
3-ISOPROPYLMALISOM-RXN show the reaction diagram,
RXN-8991 show the reaction diagram
3704,
3736
    (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
BR413 show the reaction diagram,
BR49521 show the reaction diagram,
BS1964 show the reaction diagram
R03968 show the reaction diagram,
R04001 show the reaction diagram
3-ISOPROPYLMALISOM-RXN show the reaction diagram,
RXN-8991 show the reaction diagram
3704,
3736
SPONTANEOUS   4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
  R01652 show the reaction diagram RXN-7800 show the reaction diagram  
show all sequences1.1.1.85 3-isopropylmalate dehydrogenase 4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
  R01652 show the reaction diagram RXN-7800 show the reaction diagram  
show all sequences2.6.1.1 aspartate transaminase L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
leucine degradation IV,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
BR47691 show the reaction diagram R01090 show the reaction diagram BRANCHED-CHAINAMINOTRANSFERLEU-RXN show the reaction diagram 1352
show all sequences2.6.1.42 branched-chain-amino-acid transaminase L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
leucine degradation IV,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
BR47691 show the reaction diagram R01090 show the reaction diagram BRANCHED-CHAINAMINOTRANSFERLEU-RXN show the reaction diagram 1352
show all sequences2.6.1.57 aromatic-amino-acid transaminase L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
leucine degradation IV,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
BR47691 show the reaction diagram R01090 show the reaction diagram BRANCHED-CHAINAMINOTRANSFERLEU-RXN show the reaction diagram 1352
show all sequences2.6.1.6 leucine transaminase L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
leucine degradation IV,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
BR47691 show the reaction diagram R01090 show the reaction diagram BRANCHED-CHAINAMINOTRANSFERLEU-RXN show the reaction diagram 1352
show all sequences2.6.1.67 2-aminohexanoate transaminase L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate leucine metabolism Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
leucine degradation IV,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
BR47691 show the reaction diagram R01090 show the reaction diagram BRANCHED-CHAINAMINOTRANSFERLEU-RXN show the reaction diagram 1352
show all sequences4.2.1.18 methylglutaconyl-CoA hydratase (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O leucine metabolism Valine, leucine and isoleucine degradation,
Metabolic pathways
ferrichrome A biosynthesis,
L-leucine degradation I
BR3388 show the reaction diagram R02085 show the reaction diagram METHYLGLUTACONYL-COA-HYDRATASE-RXN show the reaction diagram 2095
show all sequences1.3.8.4 isovaleryl-CoA dehydrogenase isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2 leucine metabolism Valine, leucine and isoleucine degradation,
Metabolic pathways
  BS424839 show the reaction diagram R04095 show the reaction diagram RXN-14264 show the reaction diagram 3822
show all sequences1.3.8.7 medium-chain acyl-CoA dehydrogenase isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2 leucine metabolism Valine, leucine and isoleucine degradation,
Metabolic pathways
  BS424839 show the reaction diagram R04095 show the reaction diagram RXN-14264 show the reaction diagram 3822
show all sequences6.4.1.4 methylcrotonoyl-CoA carboxylase ATP + 3-methylcrotonoyl-CoA + HCO3- + H+ = ADP + phosphate + 3-methylglutaconyl-CoA leucine metabolism Valine, leucine and isoleucine degradation,
Metabolic pathways
L-leucine degradation I BR156 show the reaction diagram R04138 show the reaction diagram METHYLCROTONYL-COA-CARBOXYLASE-RXN show the reaction diagram 3859
show all sequences4.1.1.72 branched-chain-2-oxoacid decarboxylase 2-oxoisohexanoate = CO2 + isopentanal leucine metabolism   3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
BS363284 show the reaction diagram   RXN-7692 show the reaction diagram  
show all sequences4.1.1.1 pyruvate decarboxylase 2-oxoisohexanoate = CO2 + isopentanal leucine metabolism   3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
BS363284 show the reaction diagram   RXN-7692 show the reaction diagram  
    (3R)-beta-leucine + 2-oxoglutarate = L-glutamate + beta-ketoisocaproate leucine metabolism   L-leucine degradation II     RXN-7690 show the reaction diagram  
    (2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
BR47597 show the reaction diagram,
BS373119 show the reaction diagram
R04426 show the reaction diagram 3-ISOPROPYLMALDEHYDROG-RXN show the reaction diagram  
show all sequences1.1.1.85 3-isopropylmalate dehydrogenase (2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ leucine metabolism Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
BR47597 show the reaction diagram,
BS373119 show the reaction diagram
R04426 show the reaction diagram 3-ISOPROPYLMALDEHYDROG-RXN show the reaction diagram  
show all sequences4.1.3.4 hydroxymethylglutaryl-CoA lyase (S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate leucine metabolism Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Butanoate metabolism,
Metabolic pathways
mevalonate degradation,
L-leucine degradation I,
ketogenesis
BR395 show the reaction diagram,
BS416230 show the reaction diagram
R01360 show the reaction diagram HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN show the reaction diagram 1564
show all sequences1.1.1.1 alcohol dehydrogenase 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+ leucine metabolism   3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
BR26045_WOP show the reaction diagram R05685 show the reaction diagram 1.1.1.265-RXN_WOP show the reaction diagram,
RXN-7693 show the reaction diagram
5281
show all sequences1.1.1.2 alcohol dehydrogenase (NADP+) 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+ leucine metabolism   3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
BR26045_WOP show the reaction diagram R05685 show the reaction diagram 1.1.1.265-RXN_WOP show the reaction diagram,
RXN-7693 show the reaction diagram
5281
show all sequences1.1.1.265 3-methylbutanal reductase 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+ leucine metabolism   3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
BR26045_WOP show the reaction diagram R05685 show the reaction diagram 1.1.1.265-RXN_WOP show the reaction diagram,
RXN-7693 show the reaction diagram
5281
show all sequences6.1.1.4 leucine-tRNA ligase ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu leucine metabolism     BR55 show the reaction diagram