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:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check  
Missing Substrate
Missing Product
Commentary
Remark
dethiobiotin synthase
ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways
: biotin biosynthesis from 8-amino-7-oxononanoate II,
biotin biosynthesis from 8-amino-7-oxononanoate I
: BR128 show the reaction diagram
: R03182 show the reaction diagram
: DETHIOBIOTIN-SYN-RXN show the reaction diagram
: 3011
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-
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-
natural substrates
biotin-[biotin carboxyl-carrier protein] ligase
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
: biotin biosynthesis
: biotin-carboxyl carrier protein assembly
: BR136 show the reaction diagram
: BIOTINLIG-RXN show the reaction diagram
generic compounds
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C10H14O2N2S1
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natural substrates, protein
adenosylmethionine-8-amino-7-oxononanoate transaminase
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways
: biotin biosynthesis from 8-amino-7-oxononanoate I
: BR47441 show the reaction diagram
: R03231 show the reaction diagram
: DAPASYN-RXN show the reaction diagram
: 3057
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natural substrates
lysine-8-amino-7-oxononanoate transaminase
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate
: Biotin metabolism,
Metabolic pathways
: biotin biosynthesis from 8-amino-7-oxononanoate II
: BR50965 show the reaction diagram
: R10699 show the reaction diagram
: RXN-14930 show the reaction diagram
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-
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natural substrates
biotin carboxylase
ATP + biotin-carboxyl-carrier protein + HCO3- = ADP + phosphate + carboxybiotin-carboxyl-carrier protein
: biotin biosynthesis
: BR135 show the reaction diagram, BS676 show the reaction diagram
: R04385 show the reaction diagram
: 4080
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-
: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
pyruvate carboxylase
ATP + biotin-carboxyl-carrier protein + HCO3- = ADP + phosphate + carboxybiotin-carboxyl-carrier protein
: biotin biosynthesis
: BR135 show the reaction diagram, BS676 show the reaction diagram
: R04385 show the reaction diagram
: 4080
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-
: The first step of two-step reaction (R00742) subsequently R04386
natural substrates
8-amino-7-oxononanoate synthase
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]
: biotin biosynthesis
: Biotin metabolism,
Metabolic pathways
: BR44048 show the reaction diagram
: R10124 show the reaction diagram
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-
-
-
natural substrates, generic, protein
acetyl-CoA carboxytransferase
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein <=> Malonyl-CoA + Holo-[carboxylase]
: biotin biosynthesis
: BR52249 show the reaction diagram
: R04386 show the reaction diagram
: 4081
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: The second step of two-step reaction (R00742) following after R04385
natural substrates
acetyl-CoA carboxylase
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein <=> Malonyl-CoA + Holo-[carboxylase]
: biotin biosynthesis
: BR52249 show the reaction diagram
: R04386 show the reaction diagram
: 4081
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-
-
: The second step of two-step reaction (R00742) following after R04385
natural substrates
biotin synthase
S-adenosyl-L-methionine + sulfurated [sulfur carrier] + dethiobiotin + reduced [2Fe-2S] ferredoxin = unsulfurated [sulfur carrier] + biotin + 5'-deoxyadenosine + L-methionine + oxidized [2Fe-2S] ferredoxin
: biotin biosynthesis from 8-amino-7-oxononanoate II,
biotin biosynthesis from 8-amino-7-oxononanoate I
: 2.8.1.6-RXN show the reaction diagram
generic compounds
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-
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natural substrates, generic, protein